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In Utero Antiepileptic Drug Exposure: Fetal Death and Malformations Neurol 67:407-412, Meador,K.J.,et al, 2006 See this aricle in Pubmed Article Abstract More adverse outcomes were observed in pregnancies with in utero valproate exposure vs the other antiepileptic drugs (AEDs). These results combined with several recent studies provide strong evidence that valproate poses the highest risk to the fetus. For women who fail other AEDs and require valproate, the dose should be limited if possible.

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